Detroit Lions:
| Player | Position | Injury | Wednesday* | Thursday | Friday | Game status |
|---|---|---|---|---|---|---|
| Bruce Ellington | WR | hamstring | NP | NP | NP | Out |
| Da'Shawn Hand | DE | knee | NP | NP | NP | Out |
| Kerryon Johnson | RB | knee | NP | NP | NP | Out |
| Rick Wagner | T | concussion | NP | NP | NP | Out |
| Charles Washington | DB | hamstring | NP | NP | NP | Out |
| Trevor Bates | LB | ankle | LP | LP | LP | Questionable |
| Nick Bellore | FB | ankle | LP | LP | LP | Questionable |
| Marcus Cooper Sr. | DB | back | LP | LP | LP | Questionable |
| Taylor Decker | T | shoulder | LP | LP | LP | Questionable |
| Devon Kennard | LB | hip | LP | LP | LP | Questionable |
| Matthew Stafford | QB | back | LP | LP | LP | Questionable |
*The Lions conducted a walk-through on Wednesday. Practice participation designations for that day are based on estimations
Buffalo Bills:
| Player | Position | Injury | Wednesday | Thursday | Friday | Game status |
|---|---|---|---|---|---|---|
| Ryan Lewis | CB | concussion | NP | NP | NP | Out |
| Stephen Hauschka | K | right hip | NP | NP | LP | Questionable |
| Chris Ivory | RB | shoulder | FP | FP | FP | Questionable |
| LeSean McCoy | RB | hamstring | NP | LP | LP | Questionable |
| Logan Thomas | TE | hamstring | not listed | FP | LP | Questionable |
| Derek Anderson | QB | concussion | LP | LP | FP | |
| Jason Croom | TE | groin | FP | FP | FP |
