History: Indianapolis Colts at Detroit Lions
- Will be the 43rd meeting between the two teams
- The Lions beat the Colts, 39-35, in their last meeting in 2016.
- Matthew Stafford was 31/39 with 340 passing yards 3 TDs in the win
- A Lions victory would give them consecutive victories over the Colts for the first time since doing so in the 1991 and 1997 seasons