| 2021-09-02 | Campbell and Holmes on the Lions roster |
| 2021-09-03 | Aaron Glenn mic'd Up at Lions practice |
| 2021-09-03 | High school highlights: Quarterback Jared Goff |
| 2021-09-04 | Inside the Den: Behind the Scenes with the Detroit Lions - Episode 7 |
| 2021-09-06 | Campbell on starting the regular season |
| 2021-09-06 | Okwara on personal growth on the field |
| 2021-09-06 | Hodge on taking advantage of opportunities |
| 2021-09-06 | Benson on fresh start in Detroit |
| 2021-09-07 | Season Launch Week Football Clinic |
| 2021-09-08 | Campbell on trusting his players |
| 2021-09-08 | Flowers on team mentality and culture |
| 2021-09-08 | Goff on internal expectations |
| 2021-09-08 | Reeves-Maybin on setting the tone week one |
| 2021-09-08 | Ragnow on being a team leader |
| 2021-09-08 | Anzalone on flying under the radar |
| 2021-09-09 | Lions vs. 49ers | Week 1 preview |
| 2021-09-09 | Fipp on special teams competitions |
| 2021-09-09 | Glenn on the importance of discipline |
| 2021-09-09 | Williams on getting back on the field |
| 2021-09-09 | Walker on preparing for Week 1 |
| 2021-09-09 | Hockenson on looking forward to the 2021 season ahead |
| 2021-09-10 | The X Factor: Week 1 vs San Francisco |
| 2021-09-10 | Campbell on feeling antsy for season opener |
| 2021-09-10 | Pleasant on fast flowing defense |
| 2021-09-10 | Sewell on feeling comfortable on the line |
| 2021-09-10 | Nelson on gaining experience |
| 2021-09-10 | Harris on defensive chemistry |
| 2021-09-10 | High school highlights: Tackle Penei Sewell |
| 2021-09-10 | Tasty Tailgate: Cherry Chicken Salad Wraps |
| 2021-09-11 | Lions vs 49ers: Week 1 Game Trailer |
| 2021-09-11 | 3 and Out with 49ers Senior Reporter Keiana Martin | Week 1 |
| 2021-09-11 | Lions remember September 11 |
| 2021-09-12 | HIGHLIGHT: Lions recover Garoppolo's fumbled snap |
| 2021-09-12 | HIGHLIGHT: Hockenson carries host of 49ers on 22-yard catch and run |
| 2021-09-12 | HIGHLIGHT: Goff rips TD to Hockenson on third-and-goal |
| 2021-09-12 | HIGHLIGHT: Swift capitalizes on cutback crease for 16-yard run |
| 2021-09-12 | HIGHLIGHT: Swift takes screen to the house |
| 2021-09-12 | HIGHLIGHT: Walker blitzes to bring down Garoppolo for sack |
| 2021-09-12 | HIGHLIGHT: Williams plunges ahead for his first Lions TD |
| 2021-09-12 | HIGHLIGHT: Lions recover onside kick |
| 2021-09-12 | HIGHLIGHT: Cephus high-points TD pass from Goff |
| 2021-09-12 | HIGHLIGHT: Hockenson grabs two-point conversion |
| 2021-09-12 | HIGHLIGHT: Flowers punches ball from Samuel for critical takeaway |
| 2021-09-12 | HIGHLIGHT: Cephus' phenomenal toe-tap helps him reel in two-point pass |
| 2021-09-12 | Sewell on staying within himself |
| 2021-09-12 | Goff on fight in Lions team |
| 2021-09-12 | Campbell on eliminating mistakes |
| 2021-09-13 | Jared Goff's best throws from 338-yard Lions debut Week 1 |
| 2021-09-13 | Ragnow on the Lions run game |
| 2021-09-13 | Anzalone on tough first game |
| 2021-09-15 | Cephus on building relationships on team |
| 2021-09-15 | Oruwariye on growing from late game heroics |
| 2021-09-15 | Melifonwu on the feeling going into Week 2 |
| 2021-09-15 | St. Brown on the speed of the NFL |
| 2021-09-15 | Sights and Sounds: Week 1 vs. San Francisco |
| 2021-09-15 | Women in Football Ep. 1 | Jen McCollum |
| 2021-09-16 | Campbell on challenge in facing the Packers in Week 2 |
| 2021-09-16 | Sheppard on not limiting his players |
| 2021-09-16 | The Sideline Presented by Kroger | Week 1 |
| 2021-09-16 | Goff on approaching all games the same |
| 2021-09-16 | McNeill on learning from first game |
| 2021-09-16 | Williams on returning to Green Bay for MNF |
| 2021-09-17 | Glenn on emphasizing maximum effort |
| 2021-09-17 | Staley on dynamic backfield duo |
| 2021-09-17 | Fipp on Week 1 performance |
| 2021-09-17 | Lynn on moving the football |
| 2021-09-17 | High school highlights: Tight End T.J. Hockenson |
| 2021-09-17 | Hockenson on improving through film study |
| 2021-09-17 | Jackson on playing aggressive |
| 2021-09-17 | The Sideline Presented by Kroger | Week 2 |
| 2021-09-17 | The X Factor: Week 2 vs Green Bay |
| 2021-09-18 | Campbell on the depth of the roster |
| 2021-09-18 | Wash on preparation for Week 2 matchup |
| 2021-09-19 | Lions at Packers: Week 2 Game Trailer |
| 2021-09-21 | Eli Manning dissects Jared Goff's TD pass to Quintez Cephus |
| 2021-09-21 | HIGHLIGHT: Lions' blanket coverage leads to Williams' third-down sack |
| 2021-09-21 | Peyton, Eli Manning and Gronk break down Hockenson's TD grab |
| 2021-09-21 | HIGHLIGHT: Lions' blitz pays off with crucial third-down sack of Rodgers |
| 2021-09-21 | Goff on putting the pieces in place |
| 2021-09-21 | Campbell on staying mentally tough |
| 2021-09-22 | Campbell on improvements through games |
| 2021-09-22 | Lions vs. Ravens | Week 3 preview |
| 2021-09-22 | Goff on confidence in the pass game |
| 2021-09-22 | Sights and Sounds: Week 2 at Green Bay |
| 2021-09-22 | Brockers on stopping Ravens rushing attack |
| 2021-09-23 | Campbell on roster moves |
| 2021-09-23 | Fipp on balancing players work load |
| 2021-09-23 | Staley on importance of blocking |
| 2021-09-23 | Glenn on embracing young defense |
| 2021-09-23 | Lynn on staying on the field |
| 2021-09-23 | Price on moving into larger role |
| 2021-09-23 | Parker on making the most of opportunities |
| 2021-09-23 | Reeves-Maybin on his special teams role |
| 2021-09-23 | Women in Football Ep. 2 | Liz Laux |
| 2021-09-24 | Lions vs Ravens: Week 3 Game Trailer |
| 2021-09-24 | Brunell on confidence |
| 2021-09-24 | Randle El on dynamic Ravens quarterback |
| 2021-09-24 | Barnes on preparing for enhanced role |
| 2021-09-24 | Swift on hurdling defenders |
| 2021-09-24 | High school highlights: Running back Jamaal Williams |
| 2021-09-24 | The X Factor: Week 3 vs Baltimore |
| 2021-09-24 | The Sideline Presented by Kroger | Episode 3 |
| 2021-09-25 | 3 and Out with Baltimore Ravens Reporter Garrett Downing | Week 3 |
| 2021-09-26 | Frank Ragnow Explores Osprey Nesting |
| 2021-09-26 | Oruwariye on taking the next step |
| 2021-09-26 | Harris on executing as a defense |
| 2021-09-26 | Campbell on defensive improvements |
| 2021-09-26 | Goff on resiliency of Lions team |
| 2021-09-27 | Campbell on importance of correcting mistakes |
| 2021-09-27 | St. Louis High School Touchdown in Your Town Surprise |
| 2021-09-27 | Battle Creek Central High School Touchdown in Your Town Surprise |
| 2021-09-28 | Cheer Spotlight: Kendall C |
| 2021-09-28 | Jamaal That: Episode 2 |
| 2021-09-28 | Bryant on trusting his coaches |
| 2021-09-28 | Okwara on being patient |
| 2021-09-29 | Campbell on Week 4 matchup challenges |
| 2021-09-29 | Johnson on tight end reliability |
| 2021-09-29 | Lions at Bears | Week 4 preview |
| 2021-09-29 | Goff on optimistic Lions team |
| 2021-09-29 | Raymond on importance of practice |
| 2021-09-29 | Swift on improving his pass game |
| 2021-09-29 | Sights and Sounds: Week 3 vs Baltimore |
| 2021-09-30 | Glenn on positive defensive play |
| 2021-09-30 | Staley on daily effort from running backs |
| 2021-09-30 | Lynn on wanting to win in Detroit |
| 2021-09-30 | Hockenson on the art of blocking |
| 2021-09-30 | Ragnow on tough Week 4 matchup |
| 2021-09-30 | Women in Football Ep. 3 | Emily Griffin |
