San Francisco 49ers at Detroit Lions on September 12, 2021

San Francisco 49ers at Detroit Lions: September 12, 2021

Ford Field will be rockin' when the Lions open the 2021 regular season against the San Francisco 49ers on Sunday, September 12, at 1:00 p.m. This will be Detroit's second-consecutive home opener, after dropping a 27-23 tight contest in the final seconds to the Chicago Bears in 2020, and the first time with fans in Ford Field since the end of the 2019 season.

How to watch/listen:

History: San Francisco 49ers vs. Detroit Lions

  • Will be the 68th matchup between the two teams
  • Detroit is 18-14 at home against the 49ers
  • The teams last played in Detroit in 2015, when the Lions beat the 49ers 32-17
  • Will be Dan Campbell's first regular season game as the Head Coach of the Detroit Lions

Players and coaches to know:

SAN FRANCISCO 49ERS

DETROIT LIONS

Throwback Thursday: 1995 vs. San Francisco

Relive the Lions' dramatic 1995 victory over the San Francisco 49ers.

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