San Francisco 49ers at Detroit Lions on September 12, 2021

WEEK 1 • SUN 09/12 • FINAL

San Francisco 49ers 1-0


Detroit Lions 0-1


San Francisco 49ers at Detroit Lions: September 12, 2021

Ford Field will be rockin' when the Lions open the 2021 regular season against the San Francisco 49ers on Sunday, September 12, at 1:00 p.m. This will be Detroit's second-consecutive home opener, after dropping a 27-23 tight contest in the final seconds to the Chicago Bears in 2020, and the first regular-season game with fans at Ford Field since the end of the 2019 season.

How to watch/listen:

  • TV: FOX
  • Radio: 97.1 FM. Click here to view a complete list of affiliate stations.
  • Live streaming: Fans can watch local and primetime games FOR FREE on their phone and tablet devices through Yahoo! Sports. Links to watch become available once the game begins. Simply go to or the Detroit Lions Mobile App and click on the banner at the top of the page once the game has started.
  • Postgame: Watch LIVE press conferences immediately following the conclusion of this week's game on, the Detroit Lions Mobile App, Facebook, Twitter and Youtube. Hear from head coach, quarterback and star of the game.

Play along in the Detroit Lions Mobile App

Lions Bingo: Back by popular demand, Lions Bingo presented by BetMGM, returns for the 2021 season. Set your board, watch the game, and win fantastic weekly prizes! In addition to the weekly prize for the first Blackout Bingo winner, a Bingo earns you one entry into the monthly drawing for a $100 gift card to the Lions Team Shop, an Arch Bingo earns five entries and a Blackout Bingo earns you 10 entries.

Lions Predict: Put your football knowledge to the test with Lions Predict, presented by WynnBet. How many points will the Lions score this week? Which Lion will lead the team in receiving yards? Will there be a 4th quarter lead change? Answer questions like this for your chance to win! Weekly winners will receive a gift card to the Lions Team Shop. The top scorer each week will win two tickets to the next Lions home game.

History: San Francisco 49ers vs. Detroit Lions

  • Will be the 68th matchup between the two teams
  • Detroit is 18-14 at home against the 49ers
  • The teams last played in Detroit in 2015, when the Lions beat the 49ers 32-17
  • Will be Dan Campbell's first regular-season game as the Head Coach of the Detroit Lions

Players and coaches to know:



Throwback Thursday: 1995 vs. San Francisco

Relive the Lions' dramatic 1995 victory over the San Francisco 49ers.



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