History: Arizona Cardinals vs. Detroit Lions
- This will be the 70th matchup between the two teams. Detroit has a 33-28-6 advantage in the series
- The Lions will play Arizona for the fourth-consecutive season
- This season, the Lions and Cardinals will meet for the 15th time since the NFL re-aligned in 2002. Arizona is the non-divisional opponent the Lions have most frequently played since the realignment.
- With a win or a tie, the Lions will have not lost to the Cardinals in four-straight games. The last four-game unbeaten streak Detroit had against Arizona was through the 1943-45 seasons, when the Cardinals were based in Chicago.
