| Player | Position | Injury | Wednesday** | Thursday | Friday | Game Status |
|---|---|---|---|---|---|---|
| Rashod Berry | OLB | NIR* | not listed | NP | ||
| Michael Brockers | DE | knee/illness/NIR* | NP | NP | ||
| Austin Bryant | OLB | shoulder | LP | NP | ||
| Taylor Decker | T | NIR* | not listed | NP | ||
| Charles Harris | OLB | NIR* | not listed | NP | ||
| T.J. Hockenson | TE | hand | LP | NP | ||
| Will Holden | T | NIR* | not listed | NP | ||
| Jonah Jackson | G | illness/NIR* | NP | NP | ||
| Jermar Jefferson | RB | illness | not listed | NP | ||
| Tommy Kraemer | G | NIR* | not listed | NP | ||
| Jessie Lemonier | OLB | NIR* | not listed | NP | ||
| Alim McNeill | NT | illness | not listed | NP | ||
| Matt Nelson | T | ankle/NIR* | LP | NP | ||
| Julian Okwara | OLB | ankle | NP | NP | ||
| Levi Onwuzurike | DE | illness | not listed | NP | ||
| John Penisini | NT | illness/NIR* | NP | NP | ||
| Jalen Reeves-Maybin | LB | shoulder | NP | NP | ||
| Penei Sewell | T | shoulder/illness/NIR* | LP | NP | ||
| D'Andre Swift | RB | shoulder | NP | NP | ||
| Halapoulivaati Vaitai | G | illness | NP | NP | ||
| Nick Williams | DE | illness/NIR* | NP | NP | ||
| Jared Goff | QB | illness | NP | FP |
*NIR = Not Injury Related – Coaching Decision
**The Lions conducted a walkthrough on Wednesday. Practice participation designations for that day are based on estimations.
***CB Bobby Price was placed on Reserve/COVID-19
