Detroit Lions:
| Player | Position | Injury | Wednesday* | Thursday | Friday | Game status |
|---|---|---|---|---|---|---|
| Andrew Donnal | OL | knee | NP | NP | NP | out |
| T.J. Lang | G | back | NP | NP | NP | out |
| Ezekiel Ansah | DE | shoulder | LP | LP | LP | questionable |
| LeGarrette Blount | RB | shoulder | FP | FP | LP | questionable |
| Matthew Stafford | QB | shin | FP | FP | FP |
* The Lions conducted a walkthrough on Wednesday. Practice participation designations for that day are based on estimations.
San Francisco 49ers:
| Player | Position | Injury | Wednesday | Thursday | Friday | Game status |
|---|---|---|---|---|---|---|
| Joshua Garnett | G | toe | NP | NP | NP | out |
| Marquise Goodwin | WR | quadricep | NP | NP | NP | out |
| Erik Magnuson | OL | hamstring | LP | LP | LP | out |
| Adrian Colbert | S | hamstring | NP | NP | LP | questionable |
| Mike Person | G | foot | NP | NP | LP | questionable |
| Malcolm Smith | LB | hamstring | NP | NP | LP | questionable |
| Jaquiski Tartt | S | shoulder | LP | LP | LP | |
| K'Waun Williams | CB | rib | LP | LP | LP | |
| Joe Staley | T | not injury related | NP | FP | FP | |
| Ahkello Witherspoon | CB | ankle | LP | FP | FP |
