Lions' defense, Start: The Jaguars don’t rank higher than 27th in any offensive category and are also without their best player in running back Maurice Jones-Drew. The Lions defense hasn’t been a big fantasy winner this season (scoring over 10 points just once this season), but this has the potential to be a good week.
Michael Vick, QB, Eagles: Vick is basically on a one-game tryout to save both his job and the Eagles season against the Saints on Monday Night Football. That’s motivation. The Saints have allowed at least 400 yards of offense in seven consecutive games with 15 touchdowns and the most fantasy points to opposing quarterbacks.
Trent Richardson, RB, Browns: Richardson had 15 fantasy points at Baltimore in Week 4. The Ravens' defense isn’t near what it used to be against the run. Four opponents have already rushed for at least 118 yards against them this season.
Owen Daniels, TE, Texans: Daniels has the fourth-most points of any tight end and faces a Bills defense that ranks 22nd against the pass. Daniels has had double-digit outputs in three of his last four games.
DeSean Jackson/Jeremy Maclin, WRs, Eagles: I wouldn’t be the least bit surprised if each of them has 100 yards against a Saints' defense that’s allowed 13 touchdowns to receivers and the most points to opposing receivers, averaging 30.6 combined points per week.
Jonathan Stewart, RB, Panthers: The Giants and Steelers have beat up the Redskins run defense for 20 and 18 points, respectively, the last two weeks. I like Stewart this week because he’s now the No. 1 back in Carolina and is being targeted a lot in the passing game, too (six targets against Bears last week).
Eli Manning, QB, Giants: After starting the season with at least 14 fantasy points in his first five games, Manning hasn’t reached 14 in his last three. He’s also facing a Steelers' pass defense that ranks No. 1 in the NFL (182.6 ypg).
Jonathan Dwyer, RB, Steelers: Dwyer has been on a role with at least 100 yards rushing in each of his last two starts, but the Steelers are expecting Rashard Mendenhall back this week and the Giants are allowing ninth-fewest points to running backs.
Torrey Smith, WR, Ravens: Since cornerback Joe Haden has returned to the Browns' secondary the last two weeks, the unit has given up the fewest points to opposing receivers. In two games against Haden and the Browns last season, Smith had a combined three catches for 70 yards.
Chris Johnson, RB, Titans: Johnson has rose from the fantasy wasteland in recent weeks to post double-digit points in his last three, but this could be a good week to sit him if you have other options. The Bears have allowed one rushing touchdown all season (Week 1) and the second-fewest points to running backs.
Tony Romo, QB, Cowboys: Romo has been a turnover prone of late (10 interceptions in last four games) and the Falcons' defense has limited Peyton Manning, Phillip Rivers and Robert Griffin III to less than 10 points.
Cecil Shorts, WR, Jaguars: He has 22 targets over the last two weeks and has become the leading receiver for Blaine Gabbert and the Jaguars. Shorts has had two consecutive weeks of double-digit fantasy production (13 and 11).
Josh Freeman, QB, Buccaneers: The Bucs signal caller has posted 92 fantasy points over his last three games with three touchdowns apiece in each game over than span. The Raiders have allowed 12 touchdowns passes and 20th against the pass.
Lance Moore, WR, Saints: In his last two games at the Superdome, Moore has a combined 190 yards and two scores. He’s only one week removed from a 121-yard performance and the Eagles are in the bottom half of the league in fantasy points allowed to receivers. Not a bad No. 2 receiver of flex option this week.
Packers' defense: Overall, defenses have scored the third-most points against the Cardinals' offense and have reached double-digit points in each of the last five games. Did anyone watch the Cardinals' offense on Monday night?
Justin Forsett, RB, Texans: Backup Ben Tate is dealing with a hamstring injury and is unlikely to play, which means Forsett takes over the backup role. The Bills are allowing the most points to opposing running backs and Forsett could be a good flex option if you’re in a bind.