Andrew Luck, QB, Colts: The Titans defense has allowed 24 touchdown passes this season, which is tied for second most in the league. They’ve allowed 10 opponents to throw for multiple touchdowns or at least 300 yards this season. Luck has failed to score 20 points at home only once this season (Buffalo, Week 12).
Kyle Rudolph, TE, Vikings: No Percy Harvin means more targets for Rudolph. He’s scored one touchdown and double-digit fantasy points in three straight games while Harvin has been out.
Randall Cobb, WR, Packers: Jordy Nelson is out for the Packers Sunday night, which means Cobb will get a good share of targets, along with Greg Jennings. Cobb was targeted 12 times in the first meeting with Detroit and had nine catches for 74 yards and a touchdown.
Bryce Brown, RB, Eagles: With LeSean McCoy on the bench with a concussion, Brown has 43 carries for 347 yards and four touchdowns and eight catches for 25 yards in starts against Carolina and Dallas (30 and 29 fantasy points). If McCoy remains out this week at Tampa Bay, Brown is a must start.
Josh Freeman, QB, Buccaneers: Through 12 games, Freeman has either thrown for 300 yards or multiple touchdowns eight times. The Eagles have allowed opposing passers to average 22.8 points this season, second most in the league.
Larry Fitzgerald, WR, Cardinals: Fitzgerald continues to struggle because of terrible play at quarterback for the Cardinals. He has six fantasy points combined in his past three games. Until the quarterback situation in improves, I’d find another option.
Ryan Mathews, RB, Chargers: Mathews hasn’t posted double-digit fantasy points since Week 5, and he doesn’t have a good matchup against a Steelers defense that has allowed the ninth-fewest points to running backs.
Tony Romo, QB, Cowboys: The Bengals defense has been sneaky good this season. They have held their past four opposing quarterbacks to 11 points or fewer.
Reggie Bush, RB, Dolphins: Bush hasn’t totaled 100 rushing yards in any of his last 10 games. The 49ers have the leagues No. 3 run defense and are giving up the second-fewest points to running backs.
Dwayne Bowe, WR, Chiefs: Bowe has been a huge disappointment. He has just two double-digit point outputs this season and hasn’t reached the end zone in his last eight games. He’ll also have Browns cornerback Joe Haden covering him and quarterback Brady Quinn throwing to him.
Bilal Powell, RB, Jets: Powell has scored at least 11 fantasy points in two of his last three games and has had at least 11 touches in his last three games.
Pierre Garcon. WR, Redskins: Garcon has scored at least 14 points in consecutive games.
Knowshon Moreno, RB, Broncos: The Raiders have allowed 13 rushing touchdowns and nine running backs have reached double digits in Fantasy points.
Chris Givens, WR, Rams: Givens has stepped up with Danny Amendola (foot) out. In the past two games, Givens has 16 catches for 207 yards and a touchdown. That’s been good for 28 fantasy points.
Riley Cooper, WR, Eagles: Without DeSean Jackson in the lineup (IR), Cooper has seen his targets increase. Cooper has at least six fantasy points in three of his last four games and is facing a Buccaneers defense that has allowed the second-most fantasy points to receivers.